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Wednesday, April 10, 2013
Roche immune therapy cancer drug shows promise in early study
By Bill Berkrot
(Reuters) - An experimental drug that spurs the immune system to fight cancer appeared to be safe and demonstrated anti-tumor activity against a variety of cancers in a small early stage study, researchers said on Tuesday.
The drug, called MPDL3280A, was discovered and is being developed by Roche's Genentech unit. The Phase 1 trial of the drug in 30 patients with advanced cancer was designed as a dose escalation study to test for toxicity at higher doses.
But researchers were also pleased to find early signs of effectiveness of the drug.
"We saw clear evidence of anti-tumor activity in a broad range of diagnoses, including lung cancer, kidney cancer, colon cancer and gastric cancer," said Dr. Michael Gordon, who presented the data on Tuesday at the American Association for Cancer Research meeting in Washington, D.C.
The drug is an engineered antibody that targets a protein called PD-L1, for programmed death-ligand 1, and enables T cells of the immune system to more effectively attack cancer cells. PD-L1 is found on the surface of many cancer cells and impairs the immune system's ability to fight the disease.
The drug was administered intravenously every three weeks, beginning with a dose of just 0.01 milligrams per kilogram of weight and increased up to a maximum dose of 20mg/kg.
"There were no dose limiting toxicities," Gordon, research director at Pinnacle Oncology Hematology in Scottsdale, Arizona, said in a telephone interview. "We achieved our highest deliverable dose without any undue toxicities."
Researchers and Genentech believe the PD-L1 approach may be more selective and safer than a similar promising class of immunotherapy called PD-1 inhibitors being developed by several other companies. The PD-1 drugs impact not only the intended target but potentially another receptor on healthy cells called PD-L2 and may cause lung inflammation that was not seen with the Roche drug, researchers said.
Although the study was very small, Gordon said he was impressed by the lasting effect of the drug in some of the advanced cancer patients in the trial, who were still alive for more than a year.
"The responses have been durable," he said. "In at least two cases there were near complete responses and patients are sustaining those responses in the absence of continued therapy and doing very well."
Roche is working on developing a diagnostic aimed at helping to better identify the patients most likely to respond to the PD-L1 drug. "It's efficacy and use will be defined by future clinical trials," Gordon said.
While the value of the Roche drug must also be determined in much larger clinical trials, Gordon was excited about the use of new immunotherapies in the war against cancer.
Bristol-Myers Squibb's Yervoy, which was approved in 2011 and uses a different mechanism to help the immune system fight cancer, was the first drug to significantly extend survival in patients with advanced melanoma, the most deadly form of skin cancer.
"I think the field of oncology is going to change dramatically with regard to their inclusion and incorporation in cancer care," Gordon said.
(This story has been fixed to correct drug identifier in the second paragraph to MPDL3280A from MPDL320A)
(Reporting by Bill Berkrot in New York; Editing by Grant McCool)
Source: http://news.yahoo.com/roche-immune-therapy-cancer-drug-shows-promise-early-153233597--finance.html
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Tuesday, April 9, 2013
New York proposes new laws against public corruption
By Daniel Trotta
NEW YORK (Reuters) - New York state Governor Andrew Cuomo proposed three new laws on Tuesday aimed at stopping government corruption, after federal prosecutors brought two criminal cases against elected officials in the state last week.
Decrying a culture of political corruption in New York and describing the two recent cases as "especially brazen and arrogant behavior," Cuomo promised to introduce the so-called Public Trust Act to the state legislature.
The act would create laws to punish bribery, scheming to corrupt the government, and failure to report corruption, he told a joint news conference with several chief prosecutors from the New York City area. It would also increase penalties for violations of existing laws.
New York state has gained a special reputation for political corruption.
Since 1999, 20 state legislators in New York have been ousted because of criminal or ethical issues, according to the good government group Citizens Union. The New York Public Interest Research Group found that, since 2007, state senators have been more likely to be arrested than to lose their seats in a general election.
"There have been too many incidents for too many years," Cuomo said. "They paint a truly ugly picture of our political landscape."
Preet Bharara, the U.S. Attorney for the Southern District of New York, brought the two cases last week. Cuomo thanked him, adding that he wanted to empower the state's 62 district attorneys to more easily prosecute public corruption.
As attorney general, before becoming governor, Cuomo sometimes passed corruption cases over to federal authorities because the U.S. laws were more stringent, he said.
Under the Public Trust Act, anyone convicted of a felony would be permanently barred from holding elected or civil office, serving as a lobbyist or doing business with the state.
"I want to strike while the iron is hot. A crisis is a terrible thing to waste," Cuomo said, referring to the scandals of last week.
On Thursday, New York State Assemblyman Eric Stevenson was charged with corruption on suspicion of taking more than $22,000 in bribes in exchange for official acts, and another state assemblyman was forced to resign after agreeing to cooperate with prosecutors as a secret informant.
On Tuesday, in a separate case, Democratic New York State Senator Malcolm Smith was arrested and charged with trying to buy a slot on the Republican ticket in New York City's mayoral race, in what prosecutors said was his central role in a series of bribery schemes that reflected pervasive corruption in New York politics.
Five other politicians - three Republicans and two Democrats - were also arrested and charged with collectively accepting more than $100,000 of bribes in meetings that took place in parked cars, hotel rooms and state offices, according to court papers.
Bribery of a public servant is currently illegal, but state prosecutors must prove there was a corrupt agreement between the person paying and the person receiving the bribe, said Mylan Denerstein, counsel to Cuomo. The proposed law would remove that "corrupt understanding" loophole and make it easier to prosecute, she said.
The "corrupting the government" provisions would introduce a new class of crime that would hold public officials and private citizens accountable for defrauding the government, Denerstein said.
The Public Trust Act would for the first time make it a crime for any public official or employee to fail to report bribery, Denerstein said.
(Reporting by Daniel Trotta in New York; Editing by Toni Reinhold)
Source: http://news.yahoo.com/york-proposes-laws-against-public-corruption-172249194.html
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Look for Less: Fergie?s Casual Cool
On Feb. 9, the pregnant singer really bumps it up in a chic maternity ensemble including a Salvatore Ferragamo python clutch. Check her out, plus our look for less.
Source: http://feeds.celebritybabies.com/~r/celebrity-babies/~3/B2MeLG7CxHQ/
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TV watchers multitasking, viewing more online -global poll
NEW YORK (Reuters) - Consumers are multitasking and using other electronic devices such as phones and tablets while they watch television, according to a survey released on Monday.
The online poll of 3,501 consumers in France, Brazil, Italy, Spain, the United Kingdom and the United States showed that an overwhelming majority, 90 percent, said they watched some video content over the Internet, with the tablet seeing the biggest increase.
"Consumers can't just watch TV anymore," said Francesco Venturini, of the management consulting and technology services firm Accenture's Media & Entertainment industry group.
"The rise in multitasking while watching TV suggests that scheduled programming, also known as Linear TV, may be losing its appeal for sophisticated users, presenting both challenges and opportunities for broadcasters and content providers," Venturini added.
According to the third annual Video Over Internet survey, 77 percent of consumers said they regularly use their computer while watching television, an increase of 16 percentage points from just a year ago.
But people also said their simultaneous computer usage is mostly unrelated to the programs they are watching.
An exception was the use of tablets, which correlated more closely with what consumers were watching compared to laptops or smartphones.
Only 17 percent of people using tablets during TV time said their activity was unrelated to the TV content they were viewing.
Tablet use during television viewing also saw the biggest increase in the past year, soaring from 11 percent to 44 percent, despite fewer people owning them compared to computers or smartphones.
The survey also found that consumers are increasingly using local online video service providers, an increase from 37 percent to 40 percent, a similar amount to the decrease in use by global providers like Netflix and YouTube.
And a majority of respondents identified traditional TV broadcasters as the providers they trusted most to offer video over the Internet on their TV screen.
Accenture consulting firm conducted the survey in February and March, with Brazil's sample disproportionately represented by urban populations. No margin of error was provided.
(Reporting by Chris Michaud; Editing by Patricia Reaney and Doina Chiacu)
Source: http://news.yahoo.com/tv-watchers-multitasking-viewing-more-online-global-poll-213337806.html
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Louisville beats Michigan to capture its third NCAA title
Montrezl Harrell and Chane Behanan celebrate Louisville's national title (Getty Images)
ATLANTA --- Two seconds still remained in Monday night's national title game when the party began.
As a sea of delirious red-clad Louisville fans pumped their fists, exchanged high-fives and raised their arms in victory, the Cardinals players and coaches did the same on the floor in celebration of a victory more than a year in the making.
Three hundred seventy-three days after its unexpected Final Four run came crashing to a halt against a superior Kentucky team last March, Louisville experienced the same joy its rival had at the Cardinals' expense. Behind 22 points from Luke Hancock, 18 from Peyton Siva and 15 from Chane Behanan, Louisville edged Michigan 82-76 in a scintillating national title game, delivering the school's third national championship and its first since 1986.
If just getting to the Final Four for the first time in seven years made last season a clear-cut success for Louisville, the Cardinals faced greater pressure this March to finish the job. Not only did they return five of their top seven players from last season, they also entered the NCAA tournament as the No. 1 overall seed after catching fire in the second half of league play and rolling to the Big East tournament title.
Louisville won't be remembered as a dominant champion in the mold of a 2012 Kentucky or a 2009 North Carolina, but the Cardinals did not collapse under the burden of high expectations. They used Kevin Ware's gruesome broken leg as inspiration to swat away Duke in the Elite Eight, they rallied from 12 down in the second half to survive Wichita State in the Final Four and they survived an otherworldly 17-point first half from reserve Spike Albrecht to beat Michigan.
Louisville's championship bolsters the legacies of those who achieved it.
Rick Pitino elevated his status among college basketball's all-time great coaches, capturing his second national title and becoming the first coach to win a championship at two different schools.
Hancock earned the honor of most outstanding player in the Final Four, another moment for his ailing father to treasure.
Siva and NBA-bound junior Gorgui Dieng ended their college careers in an ideal fashion, celebrating a title that will ensure they'll be welcomed as heroes whenever they return to Louisville.
If the past few national title games haven't always been scintillating, this one was electric from the opening tipoff until the final buzzer.
The first half was the stuff of fairytales.
Albrecht, a 5-foot-11 freshman only in the game because of early foul trouble for Trey Burke, erupted for 17 points before halftime, allowing the Wolverines to build a 12-point lead. Hancock, another reserve playing with a heavy heart because of his father's poor health, sank four 3-pointers in two minutes to bring the Cardinals all the way back.
Some semblance of normalcy returned in the second half when stars Burke and Siva stepped to the forefront. Burke scored 17 of his 24 points in the second half and kept Michigan competitive, but Siva answered with forays to the rim of his own to keep Louisville out in front.
The game swung on a critical call against Michigan with Louisville leading by three points and only five minutes to go.
Burke appeared to cleanly block Siva on a transition dunk attempt, but referees called the Michigan guard for a foul. Siva sank the free throws, sparking a quick 9-2 blitz that gave Louisville the breathing room it needed to close out the win.
The sight of Louisville players singing along with "We Are the Champions" after the game was a stark contrast to the scene in the Louisville locker room a year ago.
Speaking in hushed tones in a somber locker room after last March's crushing loss to Kentucky, Louisville players each lamented that they couldn't replay the six minutes when their title hopes slipped through their fingers after they had rallied to tie the score at 49.
One year later, the Cardinals have atoned for that loss and finished what they started.
NCAA tournament video from Yahoo! Sports
More NCAA tournament coverage from Yahoo! Sports
? Freshman's crazy alley-oop punctuates Cardinals' first-half comeback
? Rick Pitino caught off guard by celebration fireworks
? Little-known Spike Albrecht lights up first half of title game for Michigan
? Chris Webber arrival completes Fab Five appearance at final Four
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Monday, April 8, 2013
CA-BUSINESS Summary
Canada posts worst monthly job losses in more than four years
OTTAWA (Reuters) - Canada posted its worst monthly jobs loss in more than four years in March, another sign the economy is struggling to cope with weak foreign markets and a strong Canadian dollar. Canada shed 54,500 positions in March, more than wiping out the 50,700 jobs that were added in February, Statistics Canada said on Friday. Market operators had expected a modest gain of 8,500 jobs.
Canada's Flaherty: big March job losses just a snapshot in time
OTTAWA (Reuters) - Canada's job losses in March are disappointing, Canadian Finance Minister Jim Flaherty said on Friday, but he described the broader performance of employment since the global recession as much more positive. "After strong job growth in February I am disappointed with the job numbers announced by Statistics Canada today," Flaherty said in a statement, referring to the loss of 54,500 positions in the month.
Judge approves BofA $2.43 billion settlement over Merrill
NEW YORK (Reuters) - Bank of America Corp
TSX in five-day losing streak on lackluster jobs data
TORONTO (Reuters) - Canada's main stock index capped a five-day losing streak by slumping to its lowest in more than 3-1/2 months on Friday, led by declines in the financial sector, as gloomy Canadian and U.S. jobs data suggested the North American economy could be losing steam. The economic uncertainty weighed on oil prices, which fell to a five-month low, but a rising bullion price took gold shares higher.
China's big banks "faking" their micro loans: researcher
BOAO (Reuters) - China's big banks are not delivering on their promise to lend more to the smallest firms and are instead "faking" their micro loans, a researcher said on Saturday, suggesting a government drive to increase micro-lending is struggling. Ba Shusong, a researcher from the Development Research Center, a think-tank that advises China's cabinet, said the biggest Chinese banks are still setting tough collateral standards for small firms, who often cannot meet the demands.
IKEA halts moose lasagne sales after pork traces found
STOCKHOLM (Reuters) - Furniture retailer IKEA said on Saturday it had halted sales of moose lasagne after traces of pork were found in a batch of the product. Sales of the lasagne, of which about 10,000 tonnes has been produced by a Swedish supplier for IKEA, were stopped at its stores in 18 countries across Europe after tests by Belgian authorities late last month revealed traces of pork.
BizJet officers charged with bribing Latin American officials
(Reuters) - Two officers of a Lufthansa
Boeing completes 787 Dreamliner test flight for battery fix
NEW YORK (Reuters) - Boeing
Big funds pick sides as Agrium-Jana battle nears climax
TORONTO (Reuters) - Agrium Inc's fierce battle with activist investor Jana Partners could go down to the wire as Agrium's large institutional investors look to be split on who they are backing ahead of a shareholder vote at Agrium's annual meeting next week. The big Canadian fertilizer maker and farm products retailer has been locked in a war of words for months with Jana Partners, a New York-based hedge fund, over the direction the company should take. Jana has named a slate of five nominees for election to Agrium's board and the battle is now set to come to a head at Agrium's AGM on its home turf in Calgary, Alberta, on April 9.
Boeing finishes 787 testing, focus shifts to regulators
NEW YORK (Reuters) - With a successful flight on Friday, Boeing moved closer to proving that a revamped safety system can prevent batteries on its new 787 Dreamliner from catching fire or overheating, and getting back the plane into service. Friday's test flight concludes testing after little more than three weeks, and moves the Dreamliner closer to resuming passenger flights, restarting jet deliveries, and stemming millions of dollars in losses that have piled up at airlines and Boeing since the jet was grounded more than two months ago.
Source: http://news.yahoo.com/ca-business-summary-000057342--finance.html
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Saturday, April 6, 2013
"Hannibal" review: The lambs have a lot on their minds
By Tim Molloy
NEW YORK (TheWrap.com) - A lot of thought has gone into NBC's "Hannibal." Maybe too much thought.
Hannibal Lecter's world has always teemed with life, death, and the animalistic passions in between: death's head moths, man-eating pigs, and of course, the man-eating doctor himself. "Hannibal" builds out that world with deer that double as accessories to murder, fungi that want desperately to connect, and still more macabre insects.
The new series from "Pushing Daisies" creator Bryan Fuller, which debuts tonight, is a sort of prequel to "Red Dragon," the 1981 Thomas Harris novel that introduced us to Lecter and FBI profiler Will Graham. The story spawned the movie adaptation "Manhunter," a 1980s time capsule that is nonetheless engrossing; the unnecessary 2002 remake "Red Dragon"; and the flat-out flawless "Silence of the Lambs." It also led to the not-bad 2001 film "Hannibal" and 2007's dull "Hannibal Rising."
The TV series "Hannibal" fits into a time period somehow unexplored in any of those films or the novels that inspired them. By the time we met Lecter in "Red Dragon," he was a middle-aged prisoner, long ago locked up for murdering young women and eating them.
The delicious idea behind "Hannibal" is that we're meeting him when he's still young, free, and full of life - mostly other people's lives.
"Hannibal" is a prequel, like A&E's new "Bates Motel," that takes place in the present day despite occurring before a story we first heard decades ago.
The time-shift turns out to be a great idea. It signals to us that what we're about to see isn't necessarily part of the established Lecter canon, and may reduce some of the burden of trying to live up to "Silence of the Lambs."
"Hannibal" could have leaned on the Lecter legacy by just letting its titular character, played by Danish actor Mads Mikkelsen, make culinary puns and eat people from time to time. With his Hitler haircut, fastidious suits and slightly difficult-to-follow accent, Mikkelsen's Hannibal would demand your attention even if you didn't know about his unusual hobbies.
But the show puts Lecter in the background at the beginning - which turns out to be another good idea. It opens with the focus on Graham, played by an outstanding Hugh Dancy.
Graham is an FBI profiler - he's too unstable to be an agent - with a gift for imagining murders through the eyes of those who commit them. Would you believe he has a lot of bad dreams?
In "Silence," Lecter famously taunted Jodie Foster's Clarice Starling about her girlhood failure to save lambs from a slaughter. It's dogs, not lambs, who have Graham's sympathy on "Hannibal." We're told that he has both signs of Asperger's and "pure empathy," which may explain why he has trouble relating to people but lots of mercy for strays. He also begins to dream of deer, because of a new serial killer's particularly horrible ritual with his victims.
The focus on Graham, counterintuitive as it may seem given the show's title, is the best idea on "Hannibal."
Graham, not Lecter, seems unbalanced. The celebrated psychologist is summoned by FBI mastermind Jack Crawford (a not-so-good Laurence Fishburne) to take care of the brittle Graham.
That setup alone would be fodder for a richly entertaining show. In one scene, we watch Lecter serve Graham a protein scramble that probably contains human lungs as the two discuss their situation.
"I don't find you that interesting," says Graham.
"You will," Lecter gently replies.
It's a moment full of all the dark understatement that makes Hannibal so amusing at his best. ("I'm having an old friend for dinner," he once told Clarice, while preparing to kill and eat his former jailer.)
Mikkelsen gets a few such moments to shine, but he's at an early disadvantage, since he's playing a man trying to seem unsuspicious. Dancy has the meatier role: he's barely hanging on. Dancy's take on the character recalls William Peterson's in "Manhunter," but Dancy is more vulnerable.
He makes us admire Graham's gifts even as we pity him. And not just because we know he's walking blindly into Lecter's mental maw.
Dancy's talents are most clear in a moment with Fishburne in an FBI men's room. It's that rarest of scenes where one actor is very good and the other pretty bad. Dancy's every breath and tic feel authentic, but Fishburne tries to blow the doors off. He sets his over-the-top tone by screaming, "Use the ladies room!" at someone who walks in on their talk.
"Hannibal" has several moments that feel similarly off, in part because it's trying to do so much. Its fresh ideas include artisanal killings aplenty, involving antlers, fungus, and sometimes plain-old guns. One of the show's many intelligent touches is how jarring it is every time one of those guns is fired. For all the nightmarish violence - and there's a lot of it - it doesn't treat death lightly.
Sometimes the killings are too hard to keep straight, especially when Lecter gets in on them. This isn't a procedural, thank God, where Graham and Lecter work together to solve a crime each week. Instead, the crimes bleed across episodes and help build characters. It's a challenging approach, but one that deserves time to play out.
The problem with "Hannibal" - too many ideas - is infinitely preferable to the one that plagues similar dramas. Fox's "The Following," which also takes lots of inspiration from Harris' stories, borrows the blood and guts from "Silence," but forgets the brain and heart.
The first two Lecter books are all about empathy. Lecter understands everything, but feels little. Graham and Starling understand little, but feel too much. Starling cracks the Buffalo Bill case not with her analytical prowess, but by knowing where to look for secrets in a young girl's room.
"Hannibal" also rewards those who look closely. At one point, for example, someone points out that Graham is an expert at using insects to detect time of death.
Petersen's CSI character, Gil Grissom, did just that on "CSI." (And Fishburne replaced Petersen on "CSI." Maybe Lecter could tell us what it all represents.)
Director David Slade makes sure to provide lots of alternately gorgeous and ghastly visuals, and the show is already one of the best cast on television: Every actor has a unique and interesting look, giving the show a more realistic tone. Even some of the small roles are filled with great performers, notably "Kids in the Hall" comic genius Scott Thompson as - what else? - a CSI.
This time out, he doesn't crack any jokes.
Source: http://news.yahoo.com/hannibal-review-lambs-lot-minds-213342245.html
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Madonna?s Daughter Lourdes Dating ?Homeland? Star Timothee Chalamet
Madonna’s Daughter Lourdes Dating “Homeland” Star Timothee Chalamet
Madonna’s 16-year-old daughter, Lourdes Leon, is reportedly dating Timothee Chalamet of the Showtime series “Homeland”. The teens are both attending the esteemed LaGuardia High School of Music & Performing Arts. Lourdes’ new beau plays the role of Finn on the show, the son of vice-president Walden. A source said it’s “common knowledge at the school ...
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Shakira?s Main Men Practice Waiting Patiently
"Daddy and son waiting for Milan's passport!" Shakira captions this photo she Tweeted Friday of boyfriend Gerard Piqu? and their 10-week-old son.
Source: http://feeds.celebritybabies.com/~r/celebrity-babies/~3/SO79Ym6rRMw/
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Friday, April 5, 2013
Ohio judge sentences convicted 'Craigslist' killer to death
By Kim Palmer
AKRON, Ohio (Reuters) - An Ohio judge sentenced Richard Beasley to death on Thursday for the murder of three down-on-their-luck men who responded to an ad on the Craigslist website for a non-existent job.
After Summit County Common Pleas Judge Lynne Callahan imposed the sentence, Beasley, 53, told her he believed the convictions would be reversed and he would be found innocent.
"I want to make sure you understand: I have killed nobody," said Beasley, who was wearing prison red and white stripes and sitting in a wheelchair.
Beasley was convicted in March of kidnapping and killing David Pauley, 51, of Norfolk, Virginia; Ralph Geiger, 56, of Akron; and Timothy Kern, 47, of Massillon, Ohio.
He also was convicted of the attempted murder of Scott Davis, 49, a South Carolina man who answered a Craigslist ad and was shot in the arm while escaping after meeting Beasley and a teenage accomplice, Brogan Rafferty.
Jurors had unanimously recommended that Beasley be sentenced to death. Under Ohio law, the judge had the option of imposing the death penalty or sentencing him to life in prison.
(Reporting by Kim Palmer; Writing by David Bailey; Editing by Scott Malone and Doina Chiacu)
Source: http://news.yahoo.com/ohio-judge-sentences-convicted-craigslist-killer-death-142010846.html
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Wednesday, April 3, 2013
Too early for 2016? Not for Hillary Clinton's fans
Former Secretary of State Hillary Rodham Clinton addresses the Vital Voices Global Partnership 2013 Global Leadership Awards gala at the Kennedy Center for the Performing Arts in Washington, Tuesday, April 2, 2013. (AP Photo/Cliff Owen)
Former Secretary of State Hillary Rodham Clinton addresses the Vital Voices Global Partnership 2013 Global Leadership Awards gala at the Kennedy Center for the Performing Arts in Washington, Tuesday, April 2, 2013. (AP Photo/Cliff Owen)
Vice President Joe Biden and former Secretary of State Hillary Rodham Clinton appear onstage at the Vital Voices Global Partnership 2013 Global Leadership Awards gala at the Kennedy Center for the Performing Arts in Washington, Tuesday, April 2, 2013. (AP Photo/Cliff Owen)
Vital Voices Global Partnership 2013 Global Leadership Award recipients raise their arms at the end of the gala at the Kennedy Center for the Performing Arts in Washington, Tuesday, April 2, 2013. From left, Melanne Verveer, co-founder of Vital Voices, Tep Vanny, of Cambodia, Leadership in Public Life Award, Sandra Gomes Melo, Brazil, Human Rights Award, and Manal Yaish Zraig, Palestine, Economic Empowerment Award. (AP Photo/Cliff Owen)
Vice President Joe Biden addresses the Vital Voices Global Partnership 2013 Global Leadership Awards gala at the Kennedy Center for the Performing Arts in Washington, Tuesday, April 2, 2013. (AP Photo/Cliff Owen)
WASHINGTON (AP) ? Hillary Rodham Clinton stayed on safe political ground Tuesday, advocating women's rights globally in a 12-minute speech, but that was enough to excite fans imploring the former first lady, senator and secretary of state to run again for president three years from now.
Clinton, perhaps as popular as ever in her 22 years in national politics, said she has "unwavering faith in the untapped potential of women and girls." She spoke at the Vital Voices Global Leadership Awards, at Washington's Kennedy Center. The event, highlighting efforts such as expanding education for girls and fighting domestic violence worldwide, marked her first public speech since ending her much-praised stint as secretary of state.
As members of the group Ready for Hillary cheered outside, the 2016 political buzz was inevitable. Vice President Joe Biden ? another potential Democratic candidate ? spoke later at the same event.
If Clinton has any jealousy, she didn't show it. She praised Biden effusively, especially for his role in Congress' recent renewal of the Violence Against Women Act.
Biden returned the compliment a half-hour later, after Clinton had left the stage, telling the mostly female audience of more than 2,000 that "there's no woman like Hillary Clinton."
Biden said Clinton's declaration in China nearly two decades ago ? "Women's rights are human rights," she said at the time ? "still echoes forcefully around the world." Women everywhere, he said, "are entitled to every single opportunity that any man is."
Clinton, 65, has said she has no plans for a second presidential bid, but she hasn't ruled it out. Democrats argue among themselves whether she has the desire and energy to go through the grueling campaign process she knows so well. But many see her as a prohibitive favorite whose head start would be so big that other potential candidates might starve for funds and attention.
A Washington Post-ABC News poll in January found that 67 percent of Americans held a favorable view of Clinton. That's her highest rating since the poll began measuring her popularity in the 1990s. It spans her eight years in the Senate.
"It's hard to overstate the breadth and depth of enthusiasm for a Hillary run," said Doug Hattaway, a former Clinton campaign aide and now a Washington-based consultant. She built a national base of supporters in 2008, when she lost a hard-fought nomination fight to Barack Obama, and she's widely respected after her turn heading the State Department, Hattaway said.
"A lot of donors, volunteers and potential campaign workers will wait to hear what she decides before committing to other candidates," he said, although "anyone with their eye on 2016 is already working on it."
Mo Elleithee, a top spokesman for Clinton's 2008 campaign, said it's much too early to press her for an answer.
"My advice to everyone is to chill out," Elleithee said. "There's no need for all this breathless anticipation at this point," he said, and political activists should focus on next year's mid-term elections.
Noting that Clinton said she has no intention of running, he said, "I think that's where her head is." But he said he shares "the enthusiasm" for a Clinton candidacy.
There may be no one in America with a clearer view of what it takes to run for president.
Clinton was a highly visible adviser and defender of her husband, Bill, then the Arkansas governor, when he was elected president in 1992 in 1996. Her eight years as first lady included the excruciating Monica Lewinsky scandal and her husband's impeachment.
On the same day her husband's successor was elected, Clinton handily won a Senate seat from New York. She breezed to re-election in 2006 and was the early favorite for the 2008 presidential nomination.
But Obama used his early opposition to the Iraq war, plus a keen understanding of how to win small states' delegates, to outmaneuver the Clinton team. Obama promptly tapped his former rival to be secretary of state, assuring Clinton another prime post at the center of national policy and politics.
Some Democrats want the party to look to younger candidates, noting that Clinton will turn 69 shortly before Election Day 2016, and Biden will turn 74 soon after. Those drawing notice include New York Gov. Andrew Cuomo, 55, and Maryland Gov. Martin O'Malley, 50.
As runner-up in the 2008 Democratic primary, Clinton arguably is the party's heir apparent. Republicans, not Democrats, typically nominate the next-in-line contender.
With the early GOP presidential picture wildly scrambled, it's possible that Republicans will tap a newer, younger nominee while Democrats consider one of the nation's best-known figures, and certainly the most high-profile female politician.
Clinton is scheduled to speak Friday at the Women in the World Summit in New York.
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Monday, April 1, 2013
Mike McLelland, Kaufman County District Attorney, Found Dead With Wife In Texas Home
Sandy Hook Elementary
Molly Delaney, left, holds her 11-year-old daughter, Milly Delaney, during a service in honor of the victims who died a day earlier when a gunman opened fire at Sandy Hook Elementary School in Newtown, Conn., as people gathered at St. John's Episcopal Church , Saturday, Dec. 15, 2012, in the Sandy Hook village of Newtown, Conn. The massacre of 26 children and adults at Sandy Hook Elementary school elicited horror and soul-searching around the world even as it raised more basic questions about why the gunman, 20-year-old Adam Lanza, would have been driven to such a crime and how he chose his victims.
Clackamas Town Center
A security guard looks over the food court at the Clackamas Town Center mall as it opens, on Friday, Dec 14, 2012 in Portland, Ore. The mall is reopening, three days after a gunman killed two people and wounded a third amid a holiday shopping crowd estimated at 10,000. The shooter, Jacob Tyler Roberts, killed himself after the attack Tuesday afternoon.
St. Vincent's Hospital Shooting
Birmingham police arrive at the scene of a shooting at St. Vincent's Hospital on Saturday, Dec. 15, 2012 in Birmingham, Ala. Authorities in Alabama say a man opened fire the hospital, wounding an officer and two employees before he was fatally shot by police. Birmingham Police Sgt. Johnny Williams says the officer and employees suffered injuries that are not considered life-threatening.
Sikh Temple Shooting
Mourners attend the funeral and memorial service for the six victims of the Sikh temple of Wisconsin mass shooting in Oak Creek, Wis., Friday, Aug 10, 2012. The public service was held in the Oak Creek High School. Three other people were wounded in the shooting last Sunday at the temple. Wade Michael Page, 40, killed five men and one woman, and injured two other men. Authorities say Page then ambushed the first police officer who responded, shooting him nine times and leaving him in critical condition. A second officer then shot Page in the stomach, and Page took his own life with a shot to the head. (AP Photo/Jeffrey Phelps)
July 2012: Aurora, Colorado
A policeman stands outside a Century 16 movie theater in Aurora, Colo., where a heavily armed man opened fire, killing at least 12 people and injuring 50 others.
May 2012: Seattle, Wash.
Friends, family and employees react after a shooting at Cafe Racer in Seattle on May 30, 2012. A lone gunman killed four people Wednesday -- three were shot to death at a cafe, and a fourth in a carjacking. The gunman later killed himself.
April 2012: Oakland, California
Alameda County Community Food Bank workers move a memorial from a parking spot next to Oikos University in Oakland, Calif., Monday, April 23, 2012. Some students and staff members have arrived to resume class at Oikus University, the small California Christian college where seven people were shot to death earlier in April.
November 2010: Fort Hood, Texas
Panou Xiong, center, is comforted by family and friends following a Remembrance Ceremony commemorating the one-year anniversary of the worst mass shooting on a U.S. military base, where 13 people were killed and dozens wounded,, Nov. 5, 2010 in Fort Hood, Texas. Xiong's son, Pfc. Kham Xiong, was killed in the shooting.
March 2009: Kinston, Alabama
The charred Kinston, Ala. living room where suspected gunman Michael McLendon allegedly killed his mother Lisa McLendon, is photographed Wednesday, March 11, 2009. Authorities were working Wednesday to learn why a gunman set off on a rampage, killing 10 people across two rural Alabama counties.
August 2007: Blacksburg, Va.
An unidentified family member of slain Virginia Tech student Daniel Alejandro Prez Cueva, pauses at his memorial stone after the dedication of the memorial for the victims of the Virginia Tech shooting in Blacksburg, Va., Sunday, Aug. 19, 2007. More than 10,000 people gathered on the main campus lawn as Virginia Tech dedicated 32 memorial stones for those killed by a student in a mass shooting on campus last April.
April 1999: Littleton, Colo.
This aerial shows the news media compound near Columbine High School in Littleton, Colo., April 21, 1999. Media from around the world poured into the area after 15 people were killed during a shooting spree inside the school.
Source: http://www.huffingtonpost.com/2013/03/30/mike-mclelland-found-dead_n_2986663.html
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Source: http://feeds.gawker.com/~r/gizmodo/full/~3/3Z8-o85hsD4/okay-april-fools-2013-is-happening
Serena Williams beats Sharapova in Sony Open final
KEY BISCAYNE, Fla. (AP) ? Serena Williams danced to the crowd's roar, spinning and grinning, hopping and waving, then spinning some more.
If her victory celebration on the stadium court seemed well-rehearsed, it was. She earned a record sixth Key Biscayne women's title Saturday by beating familiar foil Maria Sharapova 4-6, 6-3, 6-0 at the Sony Open.
Sharapova set a new standard for futility in finals. She completed a career Grand Slam by winning the French Open last year, and won Indian Wells two weeks ago, but she's now 0-5 in Key Biscayne finals.
Sharapova playing nearly flawless tennis for an hour, before her serve and groundstrokes began to lose steam. Williams swept the last 10 games and faltered only during the trophy ceremony.
"I felt good today," she told the crowd with the smile. "It's so good to be No. 6 now ? I mean, the six-time ? oh, gosh. Thank you."
At 31, the No. 1-ranked Williams became the oldest female champion at Key Biscayne. She won the tournament for the first time since 2008 and surpassed Steffi Graf, a five-time champion.
"Serena played a great match," Sharapova said. "I'm sure we'll be playing a few more times this year."
Sharapova didn't sound thrilled by the prospect, with good reason. She has lost 11 consecutive matches against Williams and hasn't beaten her since 2004.
The men's finalists are familiar foes, too. On Sunday, 2009 champion Andy Murray will play frequent practice partner David Ferrer, who is trying to become the first Spaniard to win the men's title.
The women's final began at high noon in sunny, mild weather, and the quality of shotmaking matched the conditions in the early going. The aggressive style of both players made for slam-bang points, and the occasional long rallies had a near-capacity crowd gasping at their ferocity.
As they battled from the baseline, Sharapova built a lead by keeping Williams on the defensive, and kissed the line with a winner on consecutive points to break for a 3-2 advantage in the second set.
"I just was like, 'Serena, are you really going to get to the final and not play up to your potential?'" Williams said. "I don't think I was as energized as I could be."
Then came the turnaround. Williams ratcheted up the power, began feasting on Sharapova's tentative second serve and broke back at love, then took advantage of two double-faults by Sharapova to break again.
Williams lives 2 hours up I-95 in Palm Beach Gardens, and she made herself right at home in the final set, losing only 10 points.
"That's why she's No. 1 in the world," Sharapova said. "She's really capable of doing that. I was controlling a lot of the points in the first set and the beginning of the second. Then toward the end, I wasn't there."
Williams' late surge won cheers from the crowd, which included her sister, three-time champion Venus.
Sharapova made 80 percent of her first serves early on but finished at 63. Williams converted all seven break-point chances and had a 35-13 advantage in winners.
But Williams' standards are high, and in her postmatch news conference, she sounded as though she had lost.
"Today wasn't my day, I don't think," she said. "Maria played really the best I have seen her play, and I think she was moving unbelievable, and she was hitting winners from everywhere."
It wasn't Williams' first test this week. She trailed Dominika Cibulkova 6-2, 4-1 before rallying in the fourth round, and was annoyed to hit six double-faults in the quarterfinals.
"I'm happy to be holding the championship," she said. "It's definitely not my best tournament. I think everyone here can agree. But those are the moments that count ? when you can still come out on top."
She'll remain No. 1 and Sharapova No. 2 next week. Williams is the first No. 1-seeded woman to win the title since she was champion in 2004.
Williams' other titles at Key Biscayne came in 2002, '03, '07 and '08. Sharapova was runner-up in 2005, '06, '11 and '12.
"It's tough to lose in the final stage, because you work so hard to get there," Sharapova said. "But the more I give myself this opportunity, the better chance I have of winning."
Source: http://news.yahoo.com/serena-williams-beats-sharapova-sony-open-final-183546746--spt.html
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